Role of Anti-Depressants in Functional Dyspepsia

Uzair Yaqoob

Role of Anti-Depressants in Functional Dyspepsia

  • Author Uzair Yaqoob
  • Co-Author Syed Mohammad Mazhar Uddin, Aatera Haq
Keywords : Antidepressants; dyspepsia; functional disorders


Functional dyspepsia (FD) refers to a gastrointestinal disorder with symptoms of postprandial fullness, epigastria pain or burning and early satiety, in the absence of any organic disease explaining these symptoms. There have been vast but inconsistent data on treatment of FD. The standard treatment for FD includes dietary advice, pharmacological treatment including H2 blockers, proton pump inhibitor and prokinetics. Numerous studies have shown the efficacy of antidepressants in FD. In the Mertz trial, 71% reported improvement versus 29% on placebo. Three of the eight studies, including 379 patients, reported adverse events. Based on the limited data in the literature, we can conclude that antidepressants have an important role in the management of FD. However, larger and longer trials should be done. These trials should also pay more heed to whether the improvement in these symptoms is independent of an effect of treatment on depression. There should be more comprehensive studies comparing the classes of antidepressants, and studies on the long-term follow-ups of the patients should also be done for the treatment of FD.


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