To Study the Effect of ACE Inhibitors on Serum Cystatin C in Early Diabetic Nephropathy Patients

Author Richa Garg
Co-Author Taruna Sharma, D C Dhasmana, Minakshi Dhar, Monika Kakkar, Navin Kumar
DOI

Country : India
Subject : Pharmacology

Keywords : Diabetic Nephropathy, ACE Is, Serum Cystatin C, Urinary Albumin

Abstract

Aims & Objectives: To study the effect of ACE inhibitors on serum Cystatin C in early Diabetic Nephropathy patients.
Materials & Methods: An interventional, analytical study being conducted in the department of Pharmacology & Medicine of HIMS, Dehradun over a period of 12 months. 36 Patients fulfilling the inclusion criteria were recruited in the study & specific baseline investigations like Serum Cystatin C, HbA1c & urinary albumin were done. Drug Ramipril 2.5-5 mg was prescribed once daily for a period of 3 months after which repeat investigations were done.
Results: The average Pre and Post-therapy Serum Cystatin C levels were 0.95 mg/l and 0.73 mg/l, HbA1C was found to be 9.92% and 9.06% and urinary albumin levels were 154.37 mg/l and 145.99 mg/l respectively.
Conclusion: Post Ramipril therapy, urinary albumin and Serum Cystatin C significantly declined suggestive of improved renal function in early diabetic nephropathy.

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