Synthesis, Characterization and Studies on Anticancer activity of certain Polymers containing Arylidene moiety in their main chain
- Author C. Rajam, D. Roop Singh
- DOI
- Country : India
- Subject : Chemistry
Abstract
A series of novel random copolyesters and copolyesteramides containing arylidene moiety in their main chain were synthesized from 4.4'- oxybis(benzoic acid)/ 2,5-pyridine dicarboxylic acid and a common monomer diol, namely 2, 7-bis (4-hydroxy3-methoxybenzylidene) cycloheptanone with varying diols and diamines such as 1,8-dihydroxy anthraquinone, 4,4'- dihydroxy diphenyl, 1,4-cyclohexanediol, 4,4'- diamino diphenyl methane and 1,6- diaminohexane using diphenyl chlorophosphate as the condensing agent. Their structural features were investigated by FTIR, 1HNMR and 13CNMR spectral data and thermal behaviour was established by differential scanning calorimetry (DSC) and hot stage optical polarized microscopy (HOPM). Some of the synthesized polymers were tested for anticancer activity against lung cancer cells using MTT assay. These polymers showed strong anticancer activity against lung cancer cells and therefore have potential applications in biotechnology and biomedical science.
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