In Vitro Analysis of Anti Inflammatory and Antituberculosis Activity of Calotropis Gigantea Stem Methanolic Extract
- Author Jim Thomas
- Co-Author M. Suresh Kumar, Vasthi Kennedy Evanjelene
- DOI
- Country : India
- Subject : Biotechnology
Keywords : In vitro anti-inflammatory activity, anti-tuberculosis activity, Calotropis gigantea, Phytochemicals, Inhibition of albumin denaturation
Abstract
Methanol extract of stem of Calotropis gigantea was studied for its anti-inflammatory activity by in vitro methods. The results showed that C. gigantea Stem Methanol Extract (CGSME) at concentrations of 100,200, 400, 600 & 800 µg/ml displayed significant anti-inflammatory activity. CGSME at 800µg/ml showed % inhibition of 62.58 (P<0.01) by Bovine Serum Albumin inhibition of albumin denaturation method. CGSME at concentration of 1000μg/ml showed percentage inhibition of 81.99% and hence it is clearly evident that CGSME demonstrates significant anti tuberculosis activity. Purification of respective bioactive compounds are necessary and the purified form of these compounds can be used, which may show increased activity. This study gives an idea that compounds of CGSME can be used as lead compounds for designing potent anti-inflammatory and anti-tuberculosis drugs, which can be used for treatment of diseases such as inflammation, tumor and tuberculosis.
Jim Thomas
Superb interaction..Speedy acceptance...Professional publishing....No words to express my earnest gratitude
Replay