Influence of Male Reprodactive Tract Infection on Sperm DNA Fragmentation
- Author Tamar Didbaridze
- Co-Author Vladimer Papava, Leli Shanidze, Nino Didbaridze
- DOI
- Country : Georgia
- Subject : Microbiology
Keywords : Oxidative stress, antibiotics, infertility.
Abstract
The human spermatozoon is highly susceptible to oxidative stress. Spermatozoa were the first cell type reported to show potential susceptibility to OS. A few studies demonstrated the elevation of ROS concentration in infectious diseases. Endogenous sources of reactive oxygen is peroxidase-positive leucocytes: PNL (50%-60%) and macrophages (20%-30%). An increase in proinflammatory cytokines, such as interleukin (IL)-8, and a decrease in the antioxidant superoxide dismutase (SOD) can result in a respiratory burst, production of high levels of ROS, and ultimately, OS.
We retrospectively were studed oxidative stress levels and its correlation with sperm DNA damage in 12 seminal culture positive men before and after antioxidant and antibiotic treatment.
Patients with genitourinary infection have increased sperm DNA fragmentation. The inflammatory mediators can be a direct cause of DNA fragmentation in ejaculated spermatozoa, which can ultimately lead to limited fertilizing abilities of the germ cells.This increase is proportionally greater than the influence on classical semen parameters and could result in a decreased fertility potential.Combination of antioxidant and antibiotic therapy appears to be important in providing a remedy for infection-induced high DNA fragmentation levels. In summary, there exists a significant association between sperm DNA fragmentation, oxidative stress and infection.
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