Keywords : Synthesis, Characterization, Schiff base, Complex, antibacterial, antifungal
Abstract
The ligand, isatin-isonicotinylhydrazone (ISIS) was synthesized at room temperature by the condensation reaction of isonicotinylhydrazide and isatin. This synthesized ligand was interacted with Mn (II) salt and aniline and Fe (III) salt and aniline to obtain the two novel mixed ligand complexes. The synthesized compounds were characterized using some physicochemical properties such as melting point, solubility, conductivity and spectral analysis like infrared spectra and UV-visible spectra. The melting points of the ligand and the complexes were high (300-342oC) while the conductivities were low. From the elemental analysis, a 2:1:2 primary ligands to metal to secondary ligand molar ratio were established. The infrared spectral data revealed the bidentate coordination mode of the primary ligand from which bonding occurred through the nitrogen of the azomethine and oxygen of the carbonyl functional groups. The octahedral geometries for the complexes were elucidated from the electronic absorption spectral data obtained. Information derived from the antibacterial and antifungal studies showed that the metal complexes have higher antibacterial activities (17.0-22.0mm) than antifungal activities (9.0-13.0mm). In all, the metal complexes proved to be better antimicrobial agents than the free ligand.
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