The recent study investigated the effect of combined crude root extract of Sphenocentrum jollyanum and Baphia nitida on some liver enzymes in 15 male Wistar rats (body weight 150-200g). The rats were assigned into three groups. First and second groups were fed with 200mg/kg and 400mg/kg of crude extract of Sphenocentrum jollyanum and Baphia nitida respectively, via orogastric feeding for 60 days while the third group serves as control. Result was analyzed using One way ANOVA, followed by post hoc multiple comparisons and level of significance set at p<0.05. Liver enzymes tests were performed in the animals before and after the experiment using Randox diagnostic reagent kits. Results showed that mean serum ALT levels of rats fed with 200mg/kg were significantly (P<0.05) elevated compared 400mg/kg fed group and control. Mean serum AST of 200mg/kg fed rats had significant (P<0.05) reduction compared to 400mg/kg fed rats and control. Mean serum ALP levels of extract fed rats were elevated compared to control. However, mean ALP levels of rats fed with 200mg/kg had significant (P<0.05) increase than group fed with 400mg/kg extract. Furthermore, levels of the parameters before and after extract administrations show a significant decrease in ALP activity in the groups after administration compared to its initial levels. However, ALT and AST showed significant increased levels in the groups after administration compared to before administration. The changes in the liver enzyme levels may suggest possible effect of Sphenocentrum jollyanum and Baphia nitida and its ingestion in excess may likely lead to impaired liver function.
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