The recent study investigated the effect of aqueous leaf extract of Solanun melongena (Eggplant) on some plasma electrolytes and liver enzyme markers of diabetic mice. Twenty five male mice (body weight 40 to 45g) were randomly divided into five groups. First group served as control while 4 groups were induced diabetes by administration of alloxan (120 mg/kg i.p). Second group served as diabetic control, third, fourth and fifth group were adminstered 200, 400 and 600 mg/kg S. melongena extract for 28 days. Daily fasting blood sugar was also monitored. Electrolyte and liver function tests were performed. The result showed that serum sodium levels of untreated diabetic mice were higher than control, though the mean difference was not statistically significant (p>0.05). Diabetic Mice treated with 200 and 400 mg/Kg S. melongena extract had higher potassium levels compared to untreated diabetic. However, S. melongena extract resulted in increased bicarbonate levels, however, the mean difference were not statistically significant (p>0.05). Mean serum AST levels of untreated diabetic Mice was significantly higher (p<0.05) than control. Diabetic Mice treated with mg/kg S. melongena extract had lower serum AST compared to diabetic untreated, however the mean difference was not statistically significant (p>0.05). Serum ALT levels of untreated diabetic Mice were lower than control Mice. However, there was no significant difference (p>0.05) in serum ALT levels of extract treated mice compared to diabetic untreated. These findings suggest that garden egg leaf extract could be used in management of liver and kidney complications associated with diabetes.