The effect of obesity and smoking on testosterone level in middle age Sudanese men in Shendi town, North Sudan

The effect of obesity and smoking on testosterone level in middle age Sudanese men in Shendi town, North Sudan

Author HaghamadAllzain
Co-Author Mosab.O. Khalid, MohamedHashim.M.Omer, Khaled.H Bakheit
DOI

Country : Sudan
Subject : Biochemistry

Keywords : Obesity, BMI, WC, WHR, Testosterone, Fertility, Smoking

Abstract

Obesity is a major health problem in this century, and is associated with many endocrine disorders and metabolic diseases.
It was reported that obesity is associated with male infertility anddecreased testosterone and increased estradiol level.
Testosterone (C19H28O2) is the most important androgen in potency and quantity and required in high testicular concentration for spermatogenesis.

Objectives
The study aimed to examine the association between obesity and serum total testosterone level in middle-aged healthy Sudanese men.

Methods
It was a cross sectional, descriptive, case control study; conducted in Shendi town, River Nile State,north Sudan from April 2018 to August 2018. It included sixtymiddle aged healthy Sudanese men.Twenty of them were normal (BMI ≤25). Twenty were overweight (BMI ≥25) and twenty were obese (BMI ≥30), Testosterone level was measured by ELISA technique and its concentration was expressed as ng/ml.

Result
The study revealed significant inverse correlation of serum total testosteronewith BMI(r = - 0.787, P value = 0.000), waist circumference (WC) (r = - 0.717, P value = 0.000) and waist to hip ratio (WHR) (r = - 0.580, P value = 0.000).
The study also found insignificant relationship between age and serum total testosterone level with (P value = 0.061). It also demonstrated statistically significant decreased of serum total testosterone level with smoking with (P. value = 0.017).

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