Effective care for patients during a cardiac arrest is ensured by the provision of Cardiopulmonary Resuscitation in adherence to American Heart Association guidelines. For effective CPR to be achieved, nurses need to have the most current knowledge on CPR as per the AHA guidelines and the right skills. The objective of this study is to assess the influence of knowledge level on adherence to AHA CPR guidelines among nurses working at Kakamega County Referral Hospital, Kenya. The study adopted a descriptive research design. The target population for the study was all the nurses licensed by the Nursing Council of Kenya at Kakamega County Referral Hospital. Multi-stage cluster sampling technique was used o select a sample size of 166 nurses. A questionnaire was used in data collection. Descriptive statistics such as frequencies and percentages were carried out. A linear logistic regression was used to present the relationship between adherence to American Heart Association Cardiopulmonary Resuscitation guidelines and nurses’ knowledge level. The study established that the level of American Heart Association Cardiopulmonary Resuscitation adherence was poor. Overall, nurses’ knowledge level on American Heart Association Cardiopulmonary Resuscitation guidelines was low as evidenced by low number of respondents who had valid certificates. The logistic regression revealed a significant relationship between knowledge level and adherence to American Heart Association Cardiopulmonary Resuscitation guidelines. The study recommends that hospitals should establish a skills lab that is well equipped with an instructor for nurses to practice and perfect their skills in American Heart Association Cardiopulmonary Resuscitation guidelines.
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