Formulation and In Vitro Evaluation of Clindamycin Liquid Crystalline Gel in the Topical Skin Infection
- Country : India
- Subject : Pharmacy
Keywords : Clindamycine, liquid crystalline gel, Tween80, Cetosteryl alcohol
Abstract
Present study was focused on the formulation and invitro evaluation of novel gel containing clindamycin liquid crystalline gel. Aim of our study to devolope clindamycine in the treatment of topical skin infection in liquid crystalline gel form. This is prepared by using tween 80, cetosteryl alcohol and glycerol. Formulation G1 to G4 differs in the ratio of tween 80 and cetosteryl alcohol. Preformulation studies for pure drug was conducted formulation were evaluated on the basis of viscosity, encapsulation efficiency and invitro drug release study using Trans diffusion cell. FTIR study of pure drug, polymer and the formulation proves to have no chemical interaction. Formulation G2 had appropriate viscosity 1738.34 and highest encapsulation efficiency 94.45±0.4 .The invitro release study found to have zero order release profile compare to all other formulation that indicates diffusion as drug release mechanism. Invitro comparative evaluation of the liquid crystalline gel with that of 3 marketed samples proves that liquid crystalline gel formulation has the sustained release capability compare to other.
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