The study primarily aims to map the challenging topics in the Senior High School (SHS) core curriculum subject Earth and Life Science. It is based on the perception of two hundred forty-two (242) first-year college students in Quezon City University during the second semester of Academic Year 2020-2021. The study employed the descriptive research approach to explore the challenging topics in Earth and Life Science subject and its reasons using a researcher-made survey questionnaire. Results revealed that most of the respondents agreed that the most perceived challenging topic under Earth and Life Science is Bioenergetics. Results also showed that the primary reason why the students considered these topics to be the most challenging is that because it included terms that they are not familiar with. Results of this study serve as baseline data in developing instructional materials for the subject that will improve the teaching and learning process.
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