Evaluation of Hyperalgesic activity of oral Pantoprazole in Albino Mice

Author Subir Kumar
Co-Author Biswadeep Banerjee, Asim Kumar Ghosh
DOI https://ww

Country : India
Subject : Pharmacology

Keywords : Nociception, Substance-P, Somatostatin, NK1R, Pantoprazole

Abstract

This study was developed to know the heat and chemical induced nociception behaviour of albino mice under influence of oral Pantoprazole. Heat was induced by Eddy's hot plate, maintained at constant temperature of 55 degree Celsius. Chemical induced nociception behaviour of albino mice was done by freshly prepared 0.6% Acetic acid solution in the volume of 10ml/kg. Under Eddy's hot plate method mice shows their nociception behaviour by licking the paw or jumping the limbs. Under chemical induced method albino mice shows their nociception behaviour by abdominal contractions. Pantoprazole comes under class of proton pump inhibitors which is used for treatment of various disease related to gastrointestinal tract as peptic ulcer, gastroesophageal reflux disease, dyspepsia, Zollinger Ellison Syndrome etc. Lansoprazole should not prescribe with non-steroidal anti-inflammatory drugs as examples -Ibuprofen, Diclofenac, Aceclofenac, Etoricoxib etc, because lansoprazole can increase hyperalgesic activity of NSAIDS. Lansoprazole can increase pain threshold when it is given with NSAIDS. In hot plate method four groups has been created, each group contains 6 albino mice. Total 24 mice have been placed in hot plate method. Group one has been created as control group. In this group 10 ml/kg distilled water is administered orally, once daily four 10 days, an hour before test procedure. Each animal of group 2,3 and four is administered 1mg/kg, 2mg/kg, 3mg/kg orally once daily for 10 days an hour before test procedure. Drug treatment schedule for chemical induced method will be same as hot plate method.

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