Different functional groups which are attached to the benzene ring of chalcones can be varied to enhance activity. Thus, the present study has been carried out by synthesizing four substituted methoxy chalcones; 4ʹ- methyl - 2 - methoxychalcone (3a), 4ʹ- benzyloxy - 2¢, 4 - dihydroxy - 3 - methoxychalcone (3b), 3¢, 4¢, 5¢, 2, 3, 4 - hexamethoxychalcone (3c), 2ʹ, 6 - dihydroxy - 3 - methoxychalcone (3d) based on Claisen-Schimdt condensation method and characterized by spectral data UV, IR and 1H NMR. The synthesized chalcones (3a-3d) were evaluated for in vitro radical scavenging activity using diphenylpicrylhydrazyl (DPPH) model as well as antioxidant activity using Fe reducing power capacity. Compound 3d showed highest activity in DPPH method (IC50, 3.17) due to the presence of two phenolic –OH groups, capable to generate phenoxy radicals easily and stabilized by -OCH3 over the wide delocalized p- system. All the chalcones especially dihydroxy methoxy chalcones showed appreciable reducing activity at lower concentration. Reducing power capacity also highest (3d, absorbance 0.016 at 10 µg/mL). Therefore, compound 3d has a high potency in the future new template for antioxidant as well as health beneficiary chemical additive.
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