Formulation And Evalution of Bilayer Floating Tablet of Trandolapril and Diltiazem
- Author Pragti Banyal
- Co-Author Twinkle Garg, Dr. RB sharma
- DOI http://wwj
- Country : India
- Subject : Pharmaceutic
Keywords : Bilayered floating tablets, Trandolapril, Diltiazem immediate release, sustained release, direct compression
Abstract
Hypertension is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. Combination of ACE Inhibitor & Calcium channel blocker is found to be effective for treatment of Hypertension. The present work focuses on the formulation and evaluation of bilayer floating tablets of Trandolapril and Diltiazem. The immediate release layer of Trandolapril consists of a gas generating agent sodium bicarbonate and floating sustained release layer of Diltiazem comprised of low-density release retardant polymers like HPMC. The prepared powder blends were subjected to FTIR/DSC for any interaction Direct compression method was adopted to prepare tablets from optimized layers of immediate release and sustained release and subjected to Pre- and Post-compression parameters and results were found to be reasonably within the limits. The optimized IR layer of formulation F3 exhibited 91.5% drug release in 60 min and optimized SR layer of F3 showed 98.6% drug release in 12 hrs with buoyancy lag time of 190 sec. Optimized layers were compressed together and were subjected to evaluation of post compression parameters whose results were found to be reasonably within the IP limits. The release data were fitted to various mathematical models such as Higuchi, first order and zero order to evaluate kinetics and mechanism of drug release, and it was best fitted to First order and Higuchi's model.
Comments
No have any comment !