Staphylococcus epidermidis is a coagulase-negative species of staphylococci (CoNS) commonly found on human skin and mucous membranes as part of the normal flora. Nowadays, Staphylococcus epidermidis is considered as an important opportunistic pathogen, and the most common source of infections is medical equipment’s. Since Staphylococcus epidermidis is rapidly becoming resistant to antibiotics, our aim was to isolate active bacteriophages against them. As a result of the studies, four active virulent bacteriophages against Staphylococcus epidermidis were isolated by screening of Staphylococcus aureus phages: vB_S.e.22, vB_S.e.23, vB_S.e.39 and vB_S.e.40. The morphology of all four virions was studied, and it was determined that these phages belong to the Myoviridae family according to the Ackermann classification. These phages are characterized with lithic activity, range of action and stable lysis.
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