A Review Article on Pilea Microphylla
- Author Rameeza khathoon M.A
- Co-Author Meera Bhaskaran, Anagha Vijayan K.M, Fathimathul Nisa M.K, Aswathi D.
- DOI https://ww
- Country : India
- Subject : Pharmacognosy & Phytochemistry
Keywords : Pilea microphylla, Urticaceae, artillery plant.
Abstract
Pilea microphylla commonly known as artillery weed, rockweed or gunpowder plant is an important medicinal plant belonging to family Urticaceae. Pilea is used in Indian folk medicine to cure allergies\wounds, diuretics, treating burn & scald, childbirth problems, infertility & bacterial infection.
Study evaluated the antidiabetic potential of a flavonoid rich fraction in C57BL/KsJ-db/db mice. Antioxidant activities were tested by using DPPH free radical scavenging, & methanolic extract showed highest antioxidant potential. Polyphenolic fraction of Pilea showed antigenotoxicity or cytoprotective activity against g-radiation in V79 cells, correlating the antioxidant activity of polyphenols with their radioprotective effects. Pilea microphylla improves sperm parameters and DNA fragmentation in varicocelized rats. Toxicity assay carried out by using brine shrimps. The antimicrobial activity of Pilea microphylla extract was tested in vitro by using disc diffusion method and minimum inhibitory concentration (MIC). The antidepressant effect of P. microphylla was examined due to its rich flavonoid contents using two behavioural models, the Forced Swimming Test (FST) and Tail Suspension Test (TST) in mice. In vivo studies of anti-inflammatory and anti-diabetic activities of the methanolic extract of pilea was evaluated on paw edema in mice induced by carrageenan & OGTT (Oral glucose tolerance test) respectively.
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