A Cross-Sectional Study on Characteristics of Adult Myastenia Gravis Patients in Hospital Seberang Jaya

A Cross-Sectional Study on Characteristics of Adult Myastenia Gravis Patients in Hospital Seberang Jaya

Author Delis Suzan Marshall
Co-Author Purnima Devi Suppiah, Mann Leon Chin, Looi Irene
DOI https://ww

Country : Malaysia
Subject : Health

Keywords : Myasthenia gravis, Ocular Myasthenia, type of myasthenia, characteristic of myasthenia, Early onset Myasthenia Gravis (EOMG), Late onset Myasthenia Gravis (LOMG).

Abstract

Background and Purpose: Myasthenia gravis (MG) is an autoimmune disease that impacts an affected individual’s control of the skeletal muscles. To understand the common characteristics and comorbidities of MG patients who attended the adult neurology clinic at Hospital Seberang Jaya (HSJ), Penang from January-December 2016. Methods: This cross-sectional study reviewed sixty medical records of MG patients. The retrieved data was analyzed descriptively using SPSS version 23. Results: The mean age was 55 years, ranging from 16 to 81years old. Late Onset Myasthenia Gravis (LOMG) was more common, compared to Early Onset Myasthenia Gravis (EOMG), 34(56%) vs. 26(43%). Chinese predominated by 55%. Class I Myasthenia Gravis Foundation of America Clinical Classification (MGFAC) was the commonest. Ptosis noted in 80% of clinical manifestations. Comorbidities were associated in 40 (66.7%) of the MG patients, commonest being hypertension and diabetes. Ocular MG was more commonly seen in LOMG, compared to EOMG. Conclusion: Data from HSJ revealed, most MG patients were females, Chinese and of Class 1 type of MGFAC. LOMG was more common among the Chinese local population and among the ocular MG. Even though MG was seen more among the Chinese local population but myasthenia crises were least in them. Notable was an association between ocular MG and thyroid disease. More comorbid were seen in the LOMG. Our study did not show any association of comorbidities with worse outcome. The findings will aid primary health care to screen, formulate strategies and also improve quality of life (QoL).

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