Variety chemicals are commonly used in cosmetics as dye, colorant, thickener, fragrance, whitening agent, preservative, binding agent etc. Some of these poses little or no risk but in reality some such as Benzophenone, Formaldehyde, Coal tar etc. have been linked to serious health threats, including cancer, reproductive and neurological harm even developmental delays. Flavonoids specially chalcones and related compounds are mostly polyphenolic phytochemicals which have withdrawn intensive interest as these are natural color pigments, UV protector of plants with non-nitrogenous chromophore -CO-CH=CH- in conjugation with aromaticity and numerous biodynamic properties. So some new and structurally modified chalcones were synthesized by Claisen-Schimdt Condensation, characterized by spectral techniques (UV, IR, 1H NMR) and screened through antioxidant activity, namely Gallic acid equivalent antioxidant capacity (GEAC) assays, total antioxidant method. Among the selected chalcones 2 – chloro - 4¢ – methyl chalcone resulted in the greatest GEAC, 45.61 µg/mL as well as total antioxidant in BHT equivalence 260.11 µg/mL The potency of cosmetics additives of the compounds were examined as applied on carbomer gel (polyacryl amide), major cosmetic thickening ingredients and the stability of color and gel state being confirmed through unchanged pH (about 6.54 - 6.98) for three months. Compounds form very attractive transparent colors with gel and the binding mechanism can be explained by IR and UV spectroscopic technique.
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