Applications of differential Systems in the Chronic Myeloid Leukemia
- Author M. Ilea
- Co-Author M. Rotariu, S. S?voaia, I. Condurache, A. Gheorghita, C. Mucileanu, M. Turnea
- DOI https://ww
- Country : Romania
- Subject : Biomedical Sciences
Keywords : Chronic Myeloid Leukemia, Ordinary Differential Equations, Mathematical models, MATLAB.
Abstract
Chronic myeloid leukemia accounts for 15% of all leukemia’s in adults. CML progresses through three different phases (chronic, accelerated and blasted phase) and is usually diagnosed in the chronic phase. In the chronic phase of the disease, mature cells proliferate; in the accelerated phase, additional cytogenetic abnormalities appear; in the blast phase, the immature cells proliferate rapidly. In recent decades, the incidence rate of leukemia has increased slowly. From 2003 to 2012, the rate increased by 1.3% per year. Using a mathematical model represented by a system of two differential equations and the MATLAB program, we tried to simulate the behavior of leukemia for different values of the parameters in the model.
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