Correlation of D Dimer, HbA1c, and CRP with COVID 19 Severity
- Author Vindhya V V
- DOI https://ww
- Country : India
- Subject : Microbiology
Keywords : COVID 19, D dimer, CRP, HbA1c, Inflammation, Coagulation
Abstract
Study Overview Conducted at General Hospital, Kerala (June–September 2021) with 211 RT-PCR confirmed COVID-19 patients. Aim: To evaluate the correlation of D-dimer, CRP, and HbA1c levels with COVID-19 severity. Key Findings D-dimer: Elevated in severe cases; 46% of patients had levels between 500–1000 ng/mL, while ICU patients often exceeded 5000 ng/mL. CRP: Strongly correlated with disease severity; 19% had levels >40 mg/L, indicating critical illness. HbA1c: Majority (66%) had poor glycemic control (6–8%), with higher values linked to worse outcomes. Correlation Analysis D-dimer vs CRP: Strong positive correlation (r = 0.62, p < 0.001). HbA1c vs CRP: Moderate correlation (r = 0.35, p = 0.01). D-dimer vs HbA1c: Weak but significant correlation (r = 0.28, p = 0.04). Conclusion The study highlights a triad of hypercoagulability, hyperglycemia, and hyperinflammation: Elevated D-dimer indicates thrombotic risk. High CRP reflects systemic inflammation. Poor glycemic control (high HbA1c) worsens outcomes. Together, these biomarkers serve as prognostic indicators for identifying high-risk COVID-19 patients and guiding clinical management.
Comments
No have any comment !