Nonlinear Dynamics of Notch -Delta Signalling
- Author ADEYERA B. Aishah
- Co-Author Dikko B. Abdulaziz, Edwin S. Eyube
- DOI
- Country : Nigeria
- Subject : Physics
Keywords : Notch-Delta signalling, nonlinear dynamics thresholds, variability of signaling, cell fate determination
Abstract
This paper a standard model of Notch-Delta mediated lateral inhibition was considered and investigated the effect that transactivation of Notch by Delta and the inhibition threshold of Delta by Notch signaling (i.e. the dimensionless thresholds a and b ) would have on the dynamics of lateral inhibition for a system of two cells. It was observed that, provided there exist a degree of variability in signaling thresholds between cell pairs, the cell fates can be determined by Notch-Delta mediation and the dynamics is highly dependent on the thresholds.
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