Nonlinear Dynamics of Notch -Delta Signalling


Nonlinear Dynamics of Notch -Delta Signalling

Keywords : Notch-Delta signalling, nonlinear dynamics thresholds, variability of signaling, cell fate determination


This paper a standard model of Notch-Delta mediated lateral inhibition was considered and investigated the effect that transactivation of Notch by Delta and the inhibition threshold of Delta by Notch signaling (i.e. the dimensionless thresholds a and b ) would have on the dynamics of lateral inhibition for a system of two cells. It was observed that, provided there exist a degree of variability in signaling thresholds between cell pairs, the cell fates can be determined by Notch-Delta mediation and the dynamics is highly dependent on the thresholds.


No have any comment !
Leave a Comment