A study conducted in South-Eastern Nigeria from 2023 to 2024 aimed to assess awareness and vaccination willingness regarding Monkeypox (MPOX) among health professionals. The study recruited 500 health professionals using a convenience sampling technique and collected data through a structured questionnaire. The results showed that 70% of respondents had good knowledge of MPOX, while 60% were willing to receive the MPOX vaccine. Factors such as age, educational qualification, occupation, and geopolitical zone of residency significantly influenced knowledge levels and vaccination willingness. Specifically, health professionals aged 30-39 years, those with postgraduate degrees, and those working in tertiary hospitals demonstrated higher knowledge levels and greater willingness to receive the vaccine. The study highlights the need for sustained efforts to improve knowledge and vaccination uptake among health professionals, particularly targeting specific groups at higher risk of MPOX infection. Regular training and updates on MPOX diagnosis, treatment, and prevention are recommended for health professionals. Additionally, the study emphasizes targeting specific groups, such as younger health professionals and those working in primary healthcare facilities, who may have lower knowledge levels and be less willing to receive the vaccine. The study's findings have implications for developing effective public health strategies to prevent and control MPOX transmission. By targeting specific groups and providing regular training and updates, public health officials can improve knowledge and vaccination uptake among health professionals, ultimately reducing MPOX transmission and mitigating its impact on public health.
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